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Telomerase structure function studies using fluorescence and single molecule detection
Reference
B16587
Principal Investigator / Supervisor
Professor Sir Shankar Balasubramanian
Co-Investigators /
Co-Supervisors
Dr Mark Farrow
,
Professor David Klenerman
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
194,292
Status
Completed
Type
Research Grant
Start date
22/08/2002
End date
22/08/2005
Duration
36 months
Abstract
The proposed work will employ FRET and single molecule detection to first study the structure and conformational dynamics of the RNA component of human telomerase (hTR) in native form and as its complex with the protein component of human telomerase. The initial strategy will use synthetic labelled PNA as specific hybridisation probes. We will then build on these studies and carry out experiments to observe catalysis by human telomerase using single molecule FRET.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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