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A novel mechanism of streptococcal virulence factor binding to human fibronectin
Reference
B16527
Principal Investigator / Supervisor
Professor Iain Campbell
Co-Investigators /
Co-Supervisors
Dr Ulrich Schwarz-Linek
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
202,148
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
31/12/2004
Duration
36 months
Abstract
Fibronectin-binding bacterial surface proteins mediate adherence of the pathogen Streptococcus pyogenes to human cells, and efficient host cell invasion; processes required for initiation of infection and implicated in bacterial persistence after antibiotic treatment, respectively. These virulence factors are potential therapeutic targets, however a fundamental molecular understanding of the processes of adhesion and internalisation is lacking. Our preliminary data suggests a novel and highly efficient mechanism of binding of S. pyogenes to fibronectin. If correct, it will provide exciting insights into bacterial/host interactions and protein/protein interactions and suggest new approaches for the development of therapeutics.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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