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Paramagnetic NMR investigations of the structure and function of copper proteins
Reference
B16498
Principal Investigator / Supervisor
Professor Christopher Dennison
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
School of Chemistry
Funding type
Research
Value (£)
162,708
Status
Completed
Type
Research Grant
Start date
01/05/2002
End date
01/05/2005
Duration
36 months
Abstract
Cupredoxins are ubiquitous electron-transfer proteins, nitrite reductases are crucial to the global nitrogen cycle and laccases are multi-copper oxidases with a wide range of potential industrial applications. This proposal will focus on all the three classes of proteins utilising NMR to study their paramagnetic forms. This novel approach will be applied to the native copper proteins and also to metal-substituted derivatives. The results of the investigations will provide important details about these systems including the spin density distribution on the ligating amino-acids and mechanistic features. This information is essential for a thorough understanding of the various biological roles of copper.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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