Award details

Structure/function analysis and potential applications of a novel zymogen form of a ribosome inactivating protein

Reference	B16355
Principal Investigator / Supervisor	Professor Michael Lord
Co-Investigators / Co-Supervisors	Professor Robert Conlan, Dr Martin Hartley
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	206,920
Status	Completed
Type	Research Grant
Start date	18/02/2002
End date	18/02/2005
Duration	36 months

Abstract

Ribosome-inactivating (RIPs) from plants are enzymes that catalytically remove a specific adenine residue present in 28Sribosomal RNA, leaving ribosomes containing depurinated 28S RNA incapable of synthesising protein. These proteins fold into their catalytically-active native conformation as they are synthesised in the producing plant. Maize seeds however, synthesise a novel, completely inactive, zymogen form of a RIP that can be fully activated by proteolytic processing. We propose to examine the structure/function relationship and possible applications for this novel zymogen. In addition to characterising a novel activation step, the research has potential for vaccine development, and as the basis for a novel prodrug activation mechanism.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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