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The chemistry and properties of non-transferrin bound iron: relevance to toxicity

Reference	B15959
Principal Investigator / Supervisor	Professor Scott Heath
Co-Investigators / Co-Supervisors	Professor Robert Hider, Dr Andrew Horne
Institution	The University of Manchester
Department	Chemistry
Funding type	Research
Value (£)	128,457
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	31/01/2004
Duration	24 months

Abstract

In health, plasma iron is tightly bound to transferrin, rendering the iron unavailable to pathogenic organisms and for participation in the generation of harmful radicals. In iron overload or in conditions when haematopoiesis is suspended, transferrin becomes saturated and plasma iron is present in other molecular forms, collectively referred to as non-transferrin bound iron, or NTBI. The aim of the proposed research is to synthesise and fully characterise a series of known nuclearity iron clusters with biologically relevant ligands (e.g. citrate) as model complexes for the different isoforms of NTBI. A variety of techniques, including HPLC, FT-IT, ATR-IR and ESR will be used to fully characterise the model compounds and compare them with free and albumin-bound NTBI from patients with different disease states to aid the identification and characterisation of the major NTBI species.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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