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Extending the applicability of successful atomic resolution ab initio phasing methods for macromolecules to more limited data
Reference
B15857
Principal Investigator / Supervisor
Professor Keith Wilson
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Chemistry
Funding type
Research
Value (£)
219,484
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2005
Duration
36 months
Abstract
ACORN is a program using a fast Fourier based method for ab initio phasing which, with atomic resolution data, can rapidly solve large protein structures from very poor initial starting phases, derived either from a small fragment positioned by molecular replacement or from weak anomalous scatters such as sulphur atoms. The phase refinement combines a repertoire of direct methods techniques with simple dynamic density modification and is reliably monitored by the correlation coefficient. Preliminary results are encouraging. It is proposed to extend the method to work with lower resolution data by using more sophisticated regimes for density modification, which are less dependent on atomicity.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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