Award details

Molecular mechanisms in eukaryotic translation; a multidisciplinary initiative

Reference	B15794
Principal Investigator / Supervisor	Professor John McCarthy
Co-Investigators / Co-Supervisors	Professor Simon James Gaskell, Professor Nick Goddard, Professor Simon Hubbard, Professor David Stuart
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	548,652
Status	Completed
Type	Research Grant
Start date	01/12/2001
End date	31/05/2005
Duration	42 months

Abstract

This multidisciplinary research programme will study the molecular dynamics and structure of the yeast translation apparatus. More specifically, we will: 1. Use X-ray crystallography and electron microscopy to analyse the structures of eIF3/eIF2 and to study their interactions with the 40S subunit; 2. Use high resolution mass spectrometry techniques to characterise interactions between eIF3 subunits; 3. Study the dynamics of scanning 40S subunits using purpose-built imaging equipment and 40S-mRNA binding using novel surface plasmon resonance (SPR) procedures. Technology development will feature strongly in this work.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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