BBSRC Portfolio Analyser
Award details
Production and assembly of nuclear receptor/ coregulator complexes for structural studies
Reference
B15780
Principal Investigator / Supervisor
Professor Roderick Eliot Hubbard
Co-Investigators /
Co-Supervisors
Dr Igor Bronstein
Institution
University of York
Department
Chemistry
Funding type
Research
Value (£)
266,412
Status
Completed
Type
Research Grant
Start date
01/06/2002
End date
31/05/2005
Duration
36 months
Abstract
Ligand-inducible nuclear receptors are sequence-specific transcription factors that play a key role in gene expression. Interactions with different coactivators facilitate chromatin remodelling and communication with the basal transcriptional apparatus. Structural studies will be essential to understand the differential recruitment of coactivators by receptors in different ligand and cellular contexts. This project will develop and apply methods to overexpress, purify and characterise the oestrogen receptor and its complex with a co- activator protein, TIF2 to provide material for crystallisation and structural studies. The methods developed are a starting point for future studies of other large multi-protein complexes that mediate gene expression.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search