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The role of copper and zinc in amyloid formation and Alzheimer's disease
Reference
B15673
Principal Investigator / Supervisor
Dr John Viles
Co-Investigators /
Co-Supervisors
Institution
Queen Mary University of London
Department
Sch of Biological and Chemical Sciences
Funding type
Research
Value (£)
192,524
Status
Completed
Type
Research Grant
Start date
28/01/2002
End date
28/01/2005
Duration
36 months
Abstract
The 42-residue amyloid-beta-peptide (Abeta) has been shown to play a critical role in the initial build up of amyloid plaques and the onset of Alzheimer's disease. The project will focus on the neurotoxicity of Abeta and the possible mechanisms of amyloid formation. In particular the effects of copper and zinc binding to Abeta. The research will use a range of complementary spectroscopic and biophysical techniques, which will include NMR, circular dichroism and electron paramagnetic resonance. Copper has been linked to the neurotoxicity of Abeta via oxidative damage. The redox chemistry of Cu-Abeta at a structural level will be studied to further understand Abeta's neurotoxic effects. The solution structure of the zinc- and copper-Abeta complexes will be determined to gain an understanding of metal induced amyloid formation.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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