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Award details
Generation and selection of evolved forms of soluble human FcgammaRI (CD64); models for receptor blockade
Reference
B15663
Principal Investigator / Supervisor
Professor R Jefferis
Co-Investigators /
Co-Supervisors
Dr John Lund
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
164,052
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2004
Duration
24 months
Abstract
The area to be addressed is the enhancement of recognition of IgG/Fc for its effector ligand human FcgammaRI. CH2 domain genes will be expressed in rabbit reticulocyte and E. coli ribosome display systems with selection for PCR generated mutants on the basis of increased affinity for FcgammaRI. This project aims to evolve CH2 domains to i) enhance interaction with human FcgammaRI. ii) overcome the requirement for glycosylation of human Fc/IgG for the production of biologically active antibody forms in E. coli. The evolved products may be exploited in therapeutic antibodies or as partners in fusion proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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