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Structure and function of the sodium channel
Reference
B15499
Principal Investigator / Supervisor
Professor Bonnie Wallace
Co-Investigators /
Co-Supervisors
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
211,964
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2004
Duration
36 months
Abstract
Sodium channels are responsible for mediating the voltage-dependent sodium ion permeability in cells; a number of cardiovascular, nephrological and neurological diseases directly involving mutations in these have been identified. Sodium channels from electric eels, which are found in high abundance in electric tissue, have a high sequence identity with human sodium channels. This project will entail three-dimensional structure determination studies, including crystallisation, X-ray crystallography and circular dichroism spectroscopy, to elucidate the structure and function of sodium channels from E. electricus.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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