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Protein-carbohydrate interactions in cell communication: identification of carbohydrate ligands
Reference
B15284
Principal Investigator / Supervisor
Professor Anne Dell
Co-Investigators /
Co-Supervisors
Professor H Morris
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
206,368
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/10/2004
Duration
36 months
Abstract
High sensitivity fast atom bombardment, electrospray and laser desorption mass spectrometry screening strategies will be used to compare the glycosylation repertoire of normal and knockout mice, the latter lacking glycosyltransferase and glycosidase enzymes that provide key branching and terminal structures. The proposed work is part of an international collaboration addressing fundamental aspects of protein-carbohydrate structure/function relationships. In complementary work aimed at elucidating the roles of protein-carbohydrate interactions in the immune system we will screen for glycosylation differences in resting and activated T and B cells.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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