Award details

Structure and molecular recognition of the breast cancer susceptibility protein

Reference	B15227/2
Principal Investigator / Supervisor	Dr Michelle Webb
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Medical and Human Sciences
Funding type	Research
Value (£)	18,277
Status	Completed
Type	Research Grant
Start date	01/08/2004
End date	31/12/2004
Duration	5 months

Abstract

Mutations in the breast cancer susceptibility gene BRCA1 predispose women to breast cancer. To develop therapeutic agents targeted against proteins involved in BRCA1 mediated tumorigenesis it is vital that the BRCA1 protein and its associated interactions be fully characterised. The BRCA1 protein contains 1863 residues and shows little sequence identity with any other protein consequently, few clues to its biological function are provided by its amino acid sequence. We plan to identify structural domains in BRCA1 and provide a detailed analysis of their protein-protein interactions. In this way we hope to shed considerable light on the mechanism of BRCA1 mediated tumorigenesis.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

B15227 Structure and molecular recognition of the breast cancer susceptibility protein

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