Award details

Biophysical analysis of the molecular interactions that determine cell entry and trafficking by human adenoviruses

Reference	B15219
Principal Investigator / Supervisor	Professor George Santis
Co-Investigators / Co-Supervisors	Mr Ian Kirby, Professor Brian Sutton
Institution	King's College London
Department	GKT School of Medicine
Funding type	Research
Value (£)	170,092
Status	Completed
Type	Research Grant
Start date	01/06/2001
End date	01/06/2004
Duration	36 months

Abstract

Recent advances in our understanding of Adenovirus (Ad)- host cell interactions provide the basis for investigating the biological determinants of Ad infection, a prerequisite for developing Ad vectors for gene therapy. Our first objective is to investigate the details of the protein-protein interactions that underlie the distinct attachment and internalisation strategies employed by different Ad serotypes. The second objective is to assess how changes in Ad fibre-receptor interactions influence subsequent events in the virus life cycle. The third objective is to identify the Ad3 receptor and define the binding site on Ad3. These studies will contribute towards the development of Ad vectors for targeted gene delivery and may allow us to intervene in the diseases caused by these viruses.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search