Award details

Integrated structural mechanistic and in vivo studies of the pantothenate biosynthesis pathway

Reference	B15141
Principal Investigator / Supervisor	Professor Chris Abell
Co-Investigators / Co-Supervisors	Professor Sir Tom Blundell, Professor Alison Smith
Institution	University of Cambridge
Department	Chemistry
Funding type	Research
Value (£)	404,208
Status	Completed
Type	Research Grant
Start date	14/01/2002
End date	13/05/2005
Duration	40 months

Abstract

The overall objective of the project is to develop an integrated understanding of a complete biosynthetic pathway. We have recently solved the structures of all four enzymes on the pantothenate biosynthetic pathway. For each enzyme we now propose to: 1). Solve enzyme- ligand (substrate, cofactor, inhibitor) complexes and so characterise aspects of substrate and recognition and catalysis. This will be exploited in the design of inhibitors. 2). Devise improved assays and initiate detailed mechanistic studies. 3). Identify homologues in target organisms. In addition we propose to over- express the whole pathway in both microbes and plants, determine the subcellular location of the enzymes and investigate their interactions in vivo.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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