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Natural and unnatural small molecule catalytic oxidants from the Indo-Pacific seasquirt Lissoclinum patella

Reference	B15134
Principal Investigator / Supervisor	Professor Marcel Jaspars
Co-Investigators / Co-Supervisors	Professor Peter Robertson
Institution	University of Aberdeen
Department	Chemistry
Funding type	Research
Value (£)	156,468
Status	Completed
Type	Research Grant
Start date	27/08/2001
End date	27/08/2004
Duration	36 months

Abstract

We have recently discovered that the thiazole and oxazoline containing cyclic octapeptides, the patellamides, isolated from the ascidian Lissoclinum patella, complex with 2 Cu(II) to form catalases. This is the first natural small molecule system with a dicopper core that is capable of acting as an oxidant, and is very different from current synthetic models. We will synthesise L. patella metabolites, the patellamides, lissoclinamides and ulithiacyclamides and a short-bridge patellamide with varied side groups and study their oxidant activity by NMR, UV, ESR, XRD, EXAFS, Raman and electrochemical methods. We will study exogenous substrate reactivity, and determine if the complex can act as a chiral oxidation catalyst.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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