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A stereodifferentiated chimeric aminoglycoside library: simultaneous exploration of Neomycin and Kanamycin binding modes

Reference	B15030
Principal Investigator / Supervisor	Professor Adam Nelson
Co-Investigators / Co-Supervisors	Professor Peter Stockley
Institution	University of Leeds
Department	Sch of Chemistry
Funding type	Research
Value (£)	172,264
Status	Completed
Type	Research Grant
Start date	01/11/2001
End date	01/12/2004
Duration	37 months

Abstract

The interaction of small molecules with rRNA is timely in view of the recent structural determination of the ribosome. The aim of this research proposal is to synthesise a library of stereoisomeric aminoglycosides (which have both the ring III of the neomycin class and rings III/IV of the kanamycin class) and to investigate the molecular basis of their interaction with RNA using surface plasmon resonance. The stereoisomeric ligands will probe regions of conformational space which are not available to natural aminoglycosides. Ultimately, similar libraries of compounds may be used to select specific RNA sequences which may allow the elucidation of rules which relate ligand structure to RNA binding sequence.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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