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Award details
Development of expression systems for the production of membrane proteins for structural analysis
Reference
B14773
Principal Investigator / Supervisor
Professor So Iwata
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
164,984
Status
Completed
Type
Research Grant
Start date
07/05/2001
End date
07/05/2003
Duration
24 months
Abstract
Membrane proteins are involved in a large number of biological processes. Despite being one of the best studied organisms, only two inner membrane proteins have been solved for E. coli. Structural data for E. coli membrane proteins would increase our understanding of this useful and highly adaptable organism, allow greater insight into bacterial related disease states and provide information about homologous eukaryotic proteins. We have developed a unique expression and crystallisation approach involving the fusion of a protein of interest to a structurally defined membrane protein in order to facilitate the crystallisation of the protein of interest. The aim of this study is to apply this fusion approach to a number of E. coli membrane proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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