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Engineered strains of Streptomyces coelicolor as 'reagents' for the asymmetric synthesis of unnatural products
Reference
B14735
Principal Investigator / Supervisor
Professor Kevin Booker-Milburn
Co-Investigators /
Co-Supervisors
Professor G Richard Stephenson
Institution
University of Bristol
Department
Chemistry
Funding type
Research
Value (£)
189,612
Status
Completed
Type
Research Grant
Start date
01/06/2001
End date
01/06/2004
Duration
36 months
Abstract
Recent work from our laboratories has proved that genetically engineered strains of S. coelicolor can be used in the biotransformation of unnatural SNAc ester substrates into enantiomerically pure beta-hydroxy acids. It is the aim of this proposal to build on these results and use a number of engineered strains of S. coelicolor to perform multi-enzyme mediated transformations on simple SNAc ester substrates resulting in the asymmetric synthesis of complex actinorhodin related unnatural products. These engineered strains contain recombinant plasmids of the actinorhodin gene cluster which have had the early polyketide part of biosynthetic pathway disarmed by deletion of the crucial ketosynthase gene.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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