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A combinatorial approach to the design synthesis and properties of inhibitors of folate-dependent biochemical processes
Reference
B14716
Principal Investigator / Supervisor
Professor Mark Christopher Bagley
Co-Investigators /
Co-Supervisors
Dr James Platts
Institution
Cardiff University
Department
Chemistry
Funding type
Research
Value (£)
148,920
Status
Completed
Type
Research Grant
Start date
19/03/2001
End date
19/03/2004
Duration
36 months
Abstract
The aim of this proposal is to explore the design, synthesis and screening (in vitro and in silico) of combinatorial libraries based on inhibitors of folate-dependent enzymes. Synthetic efforts will be directed towards developing new methods to prepare libraries of potential inhibitors based on a pyrido- or pyrrolo[2,3-d]pyrimidine heterocyclic motif so that leads generated by screening (in silico) may be synthesised and tested (in vitro). The synthesis of targeted libraries of potential folate-dependent enzyme inhibitors represents a new way of analysing and developing these agents, directed towards accelerating the drug discovery process.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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