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Structural studies of GABARAP a linker of the GABA receptor to the cytoskeleton
Reference
B14715
Principal Investigator / Supervisor
Professor Nicholas Keep
Co-Investigators /
Co-Supervisors
Dr Paul Driscoll
,
Professor Stephen Moss
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
199,096
Status
Completed
Type
Research Grant
Start date
30/07/2001
End date
30/07/2004
Duration
36 months
Abstract
The GABA receptor is the crucial receiver of signals at the inhibitory synapse. The recently identified protein GABARAP has been shown to bind to the intracellular loop of the GABA receptor and to the C terminus of tubulin. It has homology to part of the microtubule associated protein 1B separately identified as binding to another class of GABA receptors. We propose to study the three dimensional structure of GABARAP and its interaction with peptides derived from the intracellular loop of GABA receptors and tubulin by a combination of X-ray crystallography, biophysical techniques and NMR.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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