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Structural studies on the respiratory oxidases
Reference
B14692
Principal Investigator / Supervisor
Professor So Iwata
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
270,236
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
08/01/2004
Duration
36 months
Abstract
Haem-copper oxidases are redox driven proton pumps that couple the reduction of molecular oxygen to water to the vectorial translocation of protons across the membrane. During the last few years our knowledge of the structure and function of the haem-copper oxidases has greatly profited from the X-ray structures of cytochrome c oxidases and site-directed mutagenesis studies on the enzymes. Now, we can design experiments aimed at targeting specific proton pumping mechanism based on these results. We have recently solved the crystal structures of cytochrome c oxidase from Rhodobacter sphaeroides and ubiquinol oxidase from E. coli. These crystals provide a unique opportunity to address the oxygen intermediate structures and the proton gating mechanism, by X-ray protein crystallography.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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