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Analysis of processive reactions on RNA using laser optical scanning
Reference
B14247
Principal Investigator / Supervisor
Professor John McCarthy
Co-Investigators /
Co-Supervisors
Dr Maria Nardelli
,
Professor Richard Snook
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
503,080
Status
Completed
Type
Research Grant
Start date
01/12/2000
End date
22/08/2004
Duration
45 months
Abstract
This interdisciplinary study will use imaging and laser optical trapping techniques combined with protein/RNA biochemistry to characterise two types of processive reaction on RNA: 1). Scanning by eukaryotic 40S ribosomal subunits, i.e. the process that precedes translation initiation; 2.) RNA-dependent RNA synthesis by the NS5B polymerase from hepatitis C virus. This will provide data on the force generation characteristics and dynamics of these molecular motors.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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