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A membrane protein reference database for circular dichroism spectroscopy
Reference
B14225
Principal Investigator / Supervisor
Professor Bonnie Wallace
Co-Investigators /
Co-Supervisors
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
182,599
Status
Completed
Type
Research Grant
Start date
13/08/2001
End date
12/03/2005
Duration
43 months
Abstract
Circular dichroism spectroscopy (CD) is an important technique for assessing secondary structures, folding pathways, and molecular interactions of proteins. However, secondary structural analyses based on CD data for membrane proteins have been limited in their effectiveness due to the inappropriateness of existing reference databases which have been derived from soluble proteins. This project will: 1) collect high resolution CD spectroscopic data on the synchrotron radiation (SRCD) station at Daresbury for the membrane proteins whose 3D structures are known from crystallography; 2) create a new reference database of secondary structures and CD spectra and a website with algorithms that can be used for empirical analyses of the structure of other membrane proteins; and 3) use this database to examine unique spectral features found in membrane proteins.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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