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Structural studies on the beta chemokine receptor D6
Reference
B14109
Principal Investigator / Supervisor
Professor Neil William Isaacs
Co-Investigators /
Co-Supervisors
Professor Gerard Graham
,
Dr Neil Hanlon
,
Professor Robert Nibbs
Institution
University of Glasgow
Department
School of Chemistry
Funding type
Research
Value (£)
1,120,371
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
31/03/2006
Duration
65 months
Abstract
We propose to overexpress, purify and crystallise the human beta-chemokine receptor D6 in order to determine the three-dimensional structure of this integral membrane, heptahelical, G-protein-coupled receptor. A further aim is to obtain crystals of a stable complex between the receptor and its chemokine ligand MIP-1 alpha for a structure determination. Mutants of the receptor will be made to determine the nature of the G-protein that interacts with the signalling receptor and to obtain a stable receptor/G-protein complex for structural studies. A final aim is to prepare a stable chemokine/receptor/G- protein complex for structural studies.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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