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Crystallisation and determination of the crystal structure of the membrane-bound ATP-dependant protease FtsH

Reference	B13998
Principal Investigator / Supervisor	Professor Anthony Wilkinson
Co-Investigators / Co-Supervisors	Professor Andrzej Brzozowski
Institution	University of York
Department	Chemistry
Funding type	Research
Value (£)	177,208
Status	Completed
Type	Research Grant
Start date	06/11/2000
End date	05/11/2003
Duration	36 months

Abstract

The objective of this proposal is to grow crystals and determine the crystal structure of E. coli FtsH, a multimeric membrane spanning ATP-dependent protease. FtsH degrades unassembled membrane proteins and cytoplasmic transcription factors associated with adaptive responses. The work aims to elucidate the structural basis of coupling between the ATPase and protease activities and the mechanism by which these cytoplasmic activities are controlled by interactions among periplasmic domains.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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