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Bordetella pertussis lipopolysaccharide: structure biosynthesis and enzymology
Reference
B13971
Principal Investigator / Supervisor
Dr Rob Field
Co-Investigators /
Co-Supervisors
Professor Duncan Maskell
Institution
University of East Anglia
Department
Chemistry
Funding type
Research
Value (£)
176,376
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
20/06/2004
Duration
42 months
Abstract
Bacterial lipopolysaccharide (LPS) is a key cell surface constituent involved in cell adhesion, virulence and pathogenesis. This study concerns LPS from Bordetella pertussis, which causes whooping cough. The specific aim of this programme is to characterise B. pertussis LPS band A trisaccharide and related structures arising from specific mutations in the wlb gene cluster, which is required for band A biosynthesis. Functions for some of the genes in this cluster have been proposed based on (weak) sequence homologies, but the role of others remain unclear. We aim to delineate the route by which band A is formed, and to verify it at the protein level by characterisation of recombinant wlb gene products that we have overexpressed in E. coli.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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