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Probing immune signalling: oligomerised T cell epitopes
Reference
B13969
Principal Investigator / Supervisor
Dr John Snaith
Co-Investigators /
Co-Supervisors
Professor Paul Moss
Institution
University of Birmingham
Department
School of Chemistry
Funding type
Research
Value (£)
184,904
Status
Completed
Type
Research Grant
Start date
08/01/2001
End date
07/01/2004
Duration
36 months
Abstract
Signalling in the immune system is currently the focus of intense debate. The increasing weight of evidence of the interaction between T cell receptors and their target peptide/MHC antigens has lead to the proposal that T cell signalling is controlled by the oligomerisation of these ternary complexes into supramolecular arrays. In this project we will probe this hypothesis by synthesising defined oligomers of known T cell epitope peptides which will template the assembly of the MHCs and T cell receptors, and determine the extent of the immune response to these compounds. By varying in a controlled fashion the number of peptides in the array and their relative orientation and spacing we will further probe the structural requirements of this signalling process.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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