BBSRC Portfolio Analyser
Award details
Structure-function analysis of the antiviral activity of microantibodies
Reference
B13917
Principal Investigator / Supervisor
Professor Nigel Dimmock
Co-Investigators /
Co-Supervisors
Professor Keith Jennings
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
202,940
Status
Completed
Type
Research Grant
Start date
16/05/2001
End date
16/11/2004
Duration
36 months
Abstract
This is an interdisciplinary structure-function analysis of the binding and antiviral activity of microantibodies; peptides derived from the CDRs of antibodies. Only two are known that have the virus-neutralising activity, and structural information (our own) is available only for the HIV-specific F58 MicroAb, thus this is the only model available to us. ESI-MS showed that the F58 MicroAb recognised the same protein and the same epitope as F58 IgG. Because the MicroAb comprises only 17 residues, techniques like H/D exchange and amino acid replacement will permit elucidation of the key binding and antiviral motifs, and allow insights into its mode of action. This work has general implications for understanding the action of antibodies.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search