BBSRC Portfolio Analyser
Award details
Design and synthesis of mimetics and antagonists of NAADP a novel Ca2+ mobilising intracellular messenger
Reference
B13890
Principal Investigator / Supervisor
Dr James Dowden
Co-Investigators /
Co-Supervisors
Professor A Galione
,
Dr Barry Potter
Institution
University of Bath
Department
Pharmacy and Pharmacology
Funding type
Research
Value (£)
329,920
Status
Completed
Type
Research Grant
Start date
12/02/2001
End date
30/09/2004
Duration
43 months
Abstract
This interdisciplinary proposal describes the synthesis and biological evaluation of novel molecular tools for the examination of the nicotinic acid adenine dinucleotide phosphate (NAADP) cellular signalling pathway. Recently identified as a new second messenger candidate NAADP releases Ca2+ from a unique Ca2+ pool. Unusually, at non-releasing, subthreshold concentrations NAADP potently inactivates the pathway in a time-dependent manner. With no pharmacological tools yet reported it is now timely to apply synthesis to initiate a program of development and evaluation of strategically designed NAADP analogues. We propose here a multidisciplinary approach to the generation and exploitation of structural diversity in NAADP.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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