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Award details
Inhibition and mode of action of gas-gangrene alpha-toxin
Reference
B13589
Principal Investigator / Supervisor
Professor David Moss
Co-Investigators /
Co-Supervisors
Dr Ajit Basak
,
Dr H Carless
Institution
Birkbeck College
Department
Biological Sciences
Funding type
Research
Value (£)
432,964
Status
Completed
Type
Research Grant
Start date
01/03/2001
End date
31/07/2004
Duration
41 months
Abstract
Inhibitor molecules against the gas-gangrene alpha-toxin will be designed, synthesised and tested. X-ray crystallography will be used to help understand the molecular basis of improved inhibition and to guide the design process. Structural studies on site-directed and chimeric constructs will assist in the understanding of how the alpha-toxin interacts with phospholipids. X-ray analysis will also show how the architecture of related phospholipases C is related to differences in their toxicities and substrate specificities. (MOD Joint Grant Scheme)
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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