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Award details
Testing and validation of time-resolved IR laser spectrometer and micro-stopped-flow system
Reference
B13536
Principal Investigator / Supervisor
Professor C Wharton
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Geography, Earth & Env Sciences
Funding type
Research
Value (£)
35,816
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/01/2001
Duration
9 months
Abstract
Resistance to beta-lactam antibiotics occurs by two mechanisms, the expression of powerful beta lactamases and slowly acylating transpeptidases. We propose to study both mechanisms by using time-resolved infrared spectroscopy. This method is capable of providing a dynamic description of hydrogen bonding and conformational distribution as well as protein perturbation in the acylenzyme reaction intermediates. This application is to fund a nine month period in which our new time- resolved IR spectrometer and associated micro-stopped-flow system will be commissioned, tested and validated, prior to being employed in a programme of studies of beta-lactam antibiotic resistance. This is in lieu of funding from Hoffman-La Roche.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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