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Award details
Design synthesis and characterisation of beta- keto-acid decarboxylases
Reference
B13440
Principal Investigator / Supervisor
Professor Rudolf Allemann
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
School of Chemistry
Funding type
Research
Value (£)
187,516
Status
Completed
Type
Research Grant
Start date
01/10/2000
End date
30/11/2003
Duration
38 months
Abstract
Previously, we have designed, synthesised, and characterised a peptide, which folded in solution and catalysed the decarboxylation of oxaloacetate. The peptide was stabilised by intermolecular interactions and its catalytic potential was therefore concentration dependent. We now wish to produce peptide catalysts that contain an active site within the stable molecular framework of small naturally occurring peptides like pancreatic polypeptide and Rop. A thorough structural, kinetic, and thermodynamic analysis will provide us with answers to fundamental questions about enzyme catalysis. Such an approach should lead to the production of peptides with improved catalytic properties and potential pharmaceutical and industrial applications.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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