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Forced and natural evolution of coupled electron/ proton chemistry
Reference
B13439
Principal Investigator / Supervisor
Professor Mike Jones
Co-Investigators /
Co-Supervisors
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
160,636
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
01/11/2003
Duration
36 months
Abstract
A combination of site-directed mutagenesis, time-resolved and steady-state spectroscopy, physiological studies and X-ray crystallography will be used to explore possible mechanisms for achieving coupled reduction and protonation of ubiquinone in a membrane-bound electron transfer protein. This will be done through the construction of a site for ubiquinone production at the QA position in the reaction centre from Rhodobacter sphaeroides. The project will also explore the application of natural selection as means of activating and optimising new mechanisms of ubiquinone reduction and protonation via the L- branch of cofactors in bacterial reaction centre.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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