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Synthesis of defined glycoproteins and their structural and biological evaluation
Reference
B13410
Principal Investigator / Supervisor
Professor Sabine Flitsch
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
214,060
Status
Completed
Type
Research Grant
Start date
06/11/2000
End date
06/11/2003
Duration
36 months
Abstract
The synthesis of defined glycosylated proteins is an important scientific goal. Based on some recently developed in vitro methodology we propose the synthesis of diversely glycosylated natural and unnatural glycoproteins. Two structurally very different proteins have been chosen as model systems for these studies: the human glycoprotein hormone erythropoietin (hEPO) and the integral membrane protein bacteriorhodopsin (bR). The synthetic glycoproteins thus generated will be studied in a series of experiments ranging from fundamental studies on the role of protein glycosylation to practical applications exploring the use of proteins as scaffolds for the polyvalent presentation of saccharides.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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