Award details

Structure determination of a preinitiation complex at an origin of DNA replication

Reference	B13405
Principal Investigator / Supervisor	Professor James Naismith
Co-Investigators / Co-Supervisors	Professor Ronald Hay, Dr Huan-Ting Liu
Institution	University of St Andrews
Department	Biology
Funding type	Research
Value (£)	599,796
Status	Completed
Type	Research Grant
Start date	10/07/2000
End date	09/06/2005
Duration	59 months

Abstract

Replication of DNA is central to life and involves many different proteins. Visualisation of the replication complex would make a leap in our understanding of DNA replication, it would have important consequences in medicine, biology and biotechnology. This proposal is aimed to provide a complete structural picture of the origin of replication. We have chosen the origin of replication from Adenovirus. The system is very appealing because the biology is well understood and in vivo experiments show it is a fully functional assembly. The origin of replication is formed by DNA and 5 proteins. We have obtained small crystals of two proteins. We propose to solve the crystal structure of the entire replication complex.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search