Award details

Cochaperone facilitated protein folding in vitro and in vivo

Reference	B13401
Principal Investigator / Supervisor	Professor Michael Cheetham
Co-Investigators / Co-Supervisors	Dr James Chapple
Institution	University College London
Department	Institute of Ophthalmology
Funding type	Research
Value (£)	227,988
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/04/2003
Duration	36 months

Abstract

The DnaJ family of cochaperones is the largest and most diverse chaperone family, with over 40 members currently described in mammals. We have identified a new DnaJ subfamily characterised by the conservation of the motif ENGQERVEVEEDG. This subfamily is also characterised by specialised patterns of expression that may be related to cell specific function or tissue development (e.g. Mrj and placenta). We have demonstrated that the prototypical member of this family, HSJ1, can act as a chaperone in vitro and in vivo, with striking differences in function between the two alternatively spliced isoforms. This proposal aims to define the molecular basis of the chaperone action of this chaperone subfamily and the different functions of the two isoforms by correlating in vitro and in vivo studies of protein structure and function.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search