Award details

Structure of the Auxin receptor ABP1

Reference	B13266
Principal Investigator / Supervisor	Professor Richard Pickersgill
Co-Investigators / Co-Supervisors	Professor Richard Napier
Institution	Queen Mary University of London
Department	Barts and The London School of Medicine
Funding type	Research
Value (£)	122,116
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/08/2003
Duration	24 months

Abstract

Auxin-Binding Protein (ABP1) is an important receptor for the plant hormone auxin which is involved with many growth and developmental responses. Like oxalate oxidase, whose structure we have just solved, ABP1 has been identified as a member of the cupin-superfamily. We shall determine the structures of a monocot (maize) and dicot (strawberry) ABP1 both free and in complex with auxin and other active site ligands by X-ray crystallography. The structures will reveal the shape and characteristics of the auxin binding sites, the nature of the conformational rearrangement involved in signal transduction and this knowledge will facilitate the advance of pharmacological techniques to identify new selective active site ligands.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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