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NMR studies of carbohydrate by papG from uropathogenic E. coli
Reference
B13220
Principal Investigator / Supervisor
Professor Steve Matthews
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
153,908
Status
Completed
Type
Research Grant
Start date
01/09/2000
End date
01/11/2003
Duration
38 months
Abstract
Uropathogenic E. coli, a common cause of infection amongst women and children, adheres to host cells through the interaction of bacterial organelles and glycoconjugates on the membrane of the host cell. Studies have shown that a 194 amino acids domain from papG is responsible for the bacterial adhesion to the glycan receptor. We propose to use NMR to determine the three- dimensional structure of this cell-binding protein both free and in complex with carbohydrate moiety analogues. This work will have great impact to the understanding of carbohydrate recognition and have implications in the exploitation of carbohydrate-protein interactions as an opening for drug intervention.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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