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Dehydrogenases and disease
Reference
B12819
Principal Investigator / Supervisor
Dr Andrea Hadfield
Co-Investigators /
Co-Supervisors
Professor R Brady
Institution
University of Bristol
Department
Biochemistry
Funding type
Research
Value (£)
201,188
Status
Completed
Type
Research Grant
Start date
14/01/2001
End date
13/07/2004
Duration
42 months
Abstract
We propose to probe the function and activity of a variety of disease-related dehydrogenases using a range of protein crystallographic techniques. The goals include the determination of the structure of ERAB, associated with neuronal degeneration in Alzheimer's disease and its complex with disease-related peptides. We will use a combination of time resolved crystallographic techniques and spectrophotometry to study the molecular changes that accompany catalysis for ASADH and HDH, essential for the pathogenesis of fungi and bacteria, and malarial lactate dehydrogenase. Through advancing our understanding of the detailed functioning of these enzymes this work should promote the use of dehydrogenases as targets for therapeutic development.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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