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Glycosylphosphatidylinositol (gpi) analogues as biological probes
Reference
B12818
Principal Investigator / Supervisor
Professor Steven Ley
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
331,104
Status
Completed
Type
Research Grant
Start date
01/02/2000
End date
01/02/2003
Duration
36 months
Abstract
Our research group is engaged in the development of new synthetic methodology and its application to biologically important molecules. We have already developed an efficient synthetic route to a GPI anchor of Trypanosoma bruceii. We now wish to use this acquired knowledge to further extend our GPI programme. We propose to synthesise a group of GPI analogues to be used as biological probes in the elucidation of the GPI anchor biosynthesis. Protein GPI anchors are ubiquitous in eukaryotic cells. Their principal function is to attach proteins to the plasma membrane. The biological role of GPI anchoring and GPI anchored proteins, as well as their biosynthesis is an area of intensive research. Studies to better understand GPI biosynthesis and its species dependent specificities may reveal potential drug targets against parasitic and fungal diseases.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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