Award details

Stereochemical mechanisms of signalling and translocation across cellular membranes

Reference	B12811
Principal Investigator / Supervisor	Professor Ben Luisi
Co-Investigators / Co-Supervisors	Professor Sir Tom Blundell, Professor Nicholas Gay, Professor Vassilis Koronakis
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	864,708
Status	Completed
Type	Research Grant
Start date	01/08/2000
End date	01/08/2005
Duration	60 months

Abstract

Crystallographic and functional studies will be undertaken of two membrane- associated systems: 1. Eukaryotic transmembrane receptors that communicate signals across membranes when activated by specific ligands. The systems of interest are the human Toll receptor pathway and the activins and their relatives. 2. Bacterial transmembrane efflux pumps that actively transport molecules across the bacterial inner and outer membranes and participate in multi-drug resistance. These systems represent multiple component assemblies, and our efforts will start with the analysis of individual components and build up the higher-order complexes. Our long-term aims are to elucidate the three dimensional structures of the active assemblies.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search