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A study of protein-protein interactions and electron transfer: structure and interactions of an unusual c-type cytochrome

Reference	B12799
Principal Investigator / Supervisor	Professor Jon Cooper
Co-Investigators / Co-Supervisors	Professor Christopher Anthony, Professor Stephen Wood
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	198,040
Status	Completed
Type	Research Grant
Start date	22/02/2000
End date	21/02/2003
Duration	36 months

Abstract

A common feature of most life forms is their dependence upon processes of electron transport, which couple oxidation reactions to production of ATP. Knowledge of these processes, and the structures underlying them, underpins our understanding of biology at the cellular and molecular levels. Our proposed project concerns the structure, function and interactions of an unusual cytochrome c. from M. cextorquens which lacks key structural features previously thought to be essential for cytochrome function. Our proposed structural studies of this protein in both redox states and its interactions with electron transport partners will involve CD and NMR spectroscopy as well as X-ray crystallography. Although the structure of mitochondrial cytochrome c was determined some years ago, many questions remain about the mechanism of cytochromes of this class, which apply generally to all electron transport proteins.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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