Award details

The investigation of molecular interactions in ribonucleic acids

Reference	B12730
Principal Investigator / Supervisor	Professor Stephanie Allen
Co-Investigators / Co-Supervisors	Professor Martyn Davies, Professor Saul Tendler
Institution	University of Nottingham
Department	Sch of Pharmacy
Funding type	Research
Value (£)	153,540
Status	Completed
Type	Research Grant
Start date	15/05/2000
End date	15/05/2003
Duration	36 months

Abstract

Ribonucleic acids (RNA) are known to play a role in numerous cellular functions including transcription, translation, catalysis and the transport of proteins across membranes. Given the central roles of RNA in cellular activity, it is therefore important to understand the molecular processes by which linear RNA molecules form the three-dimensional structures required for biological activity, and also how they in turn interact with other biomolecules such as proteins and DNA. However, due to the scarcity of available data these processes remain poorly understood. The proposed research aims to measure inter- and intramolecular interactions in RNAs directly, via the application of probe microscopy and optical trapping methods. Such experiments will offer new insights into RNA molecular interactions and folding, which will complement the existing experimental and theoretical data. These studies should therefore impact significantly on the fundamental understanding of RNA structure-function relationships and improve our knowledge of the processes involved in the conversion of genetic information into cellular activity.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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