Award details

Recognition of DNA containing dU bases by archaeal DNA polymerases

Reference	B12722
Principal Investigator / Supervisor	Professor Bernard Connolly
Co-Investigators / Co-Supervisors
Institution	Newcastle University
Department	Inst for Cell and Molecular Biosciences
Funding type	Research
Value (£)	193,162
Status	Completed
Type	Research Grant
Start date	01/02/2000
End date	01/02/2003
Duration	36 months

Abstract

My group, in collaboration with Professor L. Pearl (UCL, London) have recently described a novel property of archaeal DNA polymerases; stalling of DNA replication in response to dU bases in the template strand. It is believed that this represents the first step in a novel DNA repair pathway and that further proteins are recruited to the stalled complex to remove the dU base. The application primarily seeks to identify the regions of the archaeal polymerase responsible for dU recognition and to fully elucidate the mechanism by which dU bases are identified and polymerisation subsequently stalled. If time permits, a start will be made on the identification of 'downstream' proteins responsible for dU excision.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search