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Efficiency of Enzyme catalysis: new glycosidase models with two catalytic groups
Reference
B12720
Principal Investigator / Supervisor
Professor Anthony Kirby
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
102,384
Status
Completed
Type
Research Grant
Start date
24/07/2000
End date
24/07/2002
Duration
24 months
Abstract
The long term objective of this work is a deeper understanding of the efficiency of enzyme catalysis. We will test our most recent ideas on glycosyl transfer; the most refractory of the important very slow reactions catalysed by enzymes; taking advantage of newly developed leaving groups of unprecedented efficiency. We will design and synthesise model systems with two catalytic groups, each operating with optimal efficiency, and search for synergy between the coupled bond-making and bond-breaking processes involved. The results will impact on our fundamental understanding of enzyme catalysis, and (indirectly) on the limits of efficiency feasible in artificial enzyme systems.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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