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The molecular basis of myosin-linked regulation
Reference
B12705
Principal Investigator / Supervisor
Professor Peter Duncan Chantler
Co-Investigators /
Co-Supervisors
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
235,264
Status
Completed
Type
Research Grant
Start date
01/06/2000
End date
01/06/2003
Duration
36 months
Abstract
The mechanism of myosin-linked regulation is unknown but we hypothesise that communication between the two halves of the myosin molecule is required. While the size of a two-headed myosin molecule or functional fragment limits may direct attempt at structural determination, a preliminary model of key interactions is available and is readily testable. Here, through application of molecular genetics, protein crosslinking and fluorescence resonance energy transfer, we propose to test this model directly, targeting those residues implicated in head-head interactions. Results from these experiments will both test and extend key aspects of the model and further our understanding of the mechanism of myosin- linked regulation and cooperativity at the atomic level.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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