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The molecular basis of myosin-linked regulation

ReferenceB12705
Principal Investigator / Supervisor Professor Peter Duncan Chantler
Co-Investigators /
Co-Supervisors
Institution Royal Veterinary College
DepartmentVeterinary Basic Sciences - London
Funding typeResearch
Value (£) 235,264
StatusCompleted
TypeResearch Grant
Start date 01/06/2000
End date 01/06/2003
Duration36 months

Abstract

The mechanism of myosin-linked regulation is unknown but we hypothesise that communication between the two halves of the myosin molecule is required. While the size of a two-headed myosin molecule or functional fragment limits may direct attempt at structural determination, a preliminary model of key interactions is available and is readily testable. Here, through application of molecular genetics, protein crosslinking and fluorescence resonance energy transfer, we propose to test this model directly, targeting those residues implicated in head-head interactions. Results from these experiments will both test and extend key aspects of the model and further our understanding of the mechanism of myosin- linked regulation and cooperativity at the atomic level.

Summary

unavailable
Committee Closed Committee - Biomolecular Sciences (BMS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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