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Structure folding and activity of the Neurospora VS ribozyme
Reference
B12031
Principal Investigator / Supervisor
Professor David Lilley
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
177,776
Status
Completed
Type
Research Grant
Start date
01/04/2000
End date
01/09/2003
Duration
41 months
Abstract
The mechanism of ribozymes is tightly linked to RNA conformation. The Neurospora VS ribozyme has a 2y structure based around two three-way helical junctions, forming the structural scaffold on global folding of the ribozyme. We will analyse the conformation of the junctions in isolation, and then build back up to the full RNA structure via the double- junction unit. The RNA structure will be correlated with the activity of the ribozyme at each stage. This relatively neglected ribozyme provides an excellent opportunity to study the interrelationship between structure, folding and activity in the RNA.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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