Award details

Protein-protein interactions between the translocation domains of colicins and the Tol and Ton proteins of E. coli

Reference	B12015
Principal Investigator / Supervisor	Professor Richard James
Co-Investigators / Co-Supervisors	Professor Andrew Hemmings
Institution	University of Nottingham
Department	Sch of Molecular Sciences
Funding type	Research
Value (£)	203,230
Status	Completed
Type	Research Grant
Start date	04/07/2000
End date	04/07/2003
Duration	36 months

Abstract

A detailed understanding of the protein-protein interactions between colicin translocation domains and the ton- and tol- dependent translocation systems will address the fundamental biological question of how the cytotoxic domains of colicins are delivered across the outer membrane and periplasm of E. coli cells (in the case of colicin B), and also across the cytoplasmic membrane (in the case of colicins E2 to E9). The latter is a unique event in bacteria. This knowledge will be of value in the design of novel antibiotics as (a) the TonB protein is essential for iron acquisition by bacterial cells; (b) the Tol proteins are essential for outer membrane integrity; (c) we may be able to target other toxic polypeptides into bacterial cells.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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