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The molecular basis of beta-lactam antibiotic resistance: IR spectroscopic studies
Reference
B11926
Principal Investigator / Supervisor
Professor C Wharton
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
238,600
Status
Completed
Type
Research Grant
Start date
01/10/1999
End date
01/11/2002
Duration
37 months
Abstract
Resistance to beta-lactam antibiotics occurs by two mechanisms, the expression of powerful beta lactamases and slowly acylating transpeptidases and is intellectually challenging as well as important for society. We propose to study both mechanisms by using time- resolved infrared spectroscopy. This method is capable of providing a dynamic description of both hydrogen bonding and conformational distribution as well as protein perturbation in the acylenzyme structures and calculation of IR vibrational frequencies to allow prediction of novel structures from spectra. The method will be rapid and have general utility.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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